一、基本信息

汤熙翔，男，1974年1月生。研究员。

二、研究领域

深海微生物环境适应性机制及生物活性物质的应用开发，主要研究方向包括：

1. 深海耐嗜压和耐嗜冷细菌的多样性及新种分类鉴定研究；

2. 深海耐嗜压和耐嗜冷细菌的高压和低温适应性机制研究；

3. 深海微生物次生代谢产物在农业领域的应用基础及开发研究；

4. 深海微生物次生代谢产物在生物医药领域的应用基础及开发研究。

承担的课题：

1．海洋生物医药产业规划与政策研究（中国自然资源部课题，省部级，课题负责人，720万元）；

2. 农用深海微生物筛选、潜力评价与开发利用（中国大洋矿产资源研究开发协会课题，省部级，子课题负责人，91万元）；

3. 深海微生物天然药物新资源获取与活性评价（中国大洋矿产资源研究开发协会课题，省部级，子课题负责人，50万元）；

4. 深海酵母来源功能性水产饲料添加剂的研制（福建省科技计划重点课题，省部级，课题负责人，15万元）；

5. 超深渊生物群落及其与关键环境要素的相互作用机制研究（国家重点基础研究发展计划（973计划）子课题，国家级，子课题负责人，98万元）。

五、近期发表的文章：

1. Tang X，Yan X, Fu W, Yi L, Tang B, Yu L, Fang M, Wu Z, and Qiu Y. New β-Lactone with Tea Pathogenic Fungus Inhibitory Effect from Marine-derived Fungus MCCC3A00957. J Agric Food Chem. 2019 Feb 26.

doi: 10.1021/acs.jafc.9b00228.

2. Yu L, Tang X（co-first，co-correspond）, Wei S, Qiu Y, Xu X, Wang Q, Xu G, , Yang Q.  Isolation and characterization of a novel piezotolerant bacterium Lysinibacillus yapensis sp. nov., from deep-sea sediment of the Yap Trench, Pacific Ocean. Journal of Microbiology. 2019,57, DOI 10.1007/s12275-019-8709-3

3. Zhang X, Tang X（co-first）, Tran NT, Huang Y, Gong Y, Zhang Y, Zheng H, Ma H, Li S. Innate immune responses and metabolic alterations of mud crab (Scylla paramamosain) in response to Vibrio parahaemolyticus infection.Fish Shellfish Immunol. 2019 Jan 9;87:166-177.

4. Li W, Tang X（co-first）, Chen Y, Sun W, Liu Y, Gong Y, Wen X, Li S. Characterize a typically Dscam with alternative splicing in mud crab Scylla paramamosain.Fish Shellfish Immunol. 2017 Dec;71:305-318.

5. Yan X, Tang X（co-first）, Qin D, Yi ZW, Fang MJ, Wu Z, QiuYK. Biosynthetic Functional Gene Analysis of Bis-Indole Metabolites from 25D7, a Clone Derived from a Deep-Sea Sediment Metagenomic Library.Mar Drugs. 2016 Jun 1;14(6).

6.  Li W, Tang X（co-first）, Yan X, Wu Z, Yi ZW, Fang MJ, Su X, Qiu YK.A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5.

Nat Prod Res. 2016 Apr 13:1-6.

7. Yan X, Tang X（co-first）, Chen L, Yi ZW, Fang MJ, Wu Z, Qiu YK.Two new cytotoxic indole alkaloids from a deep-sea sediment derived metagenomic clone.Mar Drugs. 2014 Apr 8;12(4):2156-63.

8. Yu L, Zhou Z, Wei S, Xu X, Wang Q, Xu G, Tang X(co-correspond), Yang Q. Marinomonas piezotolerans sp. nov., isolated from deep-sea sediment of the Yap Trench, Pacific Ocean.Int J Syst Evol Microbiol. 2019 Jan 16. doi: 10.1099/ijsem.0.003227. 

9. Niu SW, Tang X, Fan ZW, Xia JM, Xie CL, Yang XW. Fusarisolins A−E, Polyketides from the Marine-Derived Fungus Fusarium solani H918. Mar Drugs. 2019 Feb 20;17(2). pii: E125. 

10. Liu SZ, Yan X, Tang X, Lin JG, Qiu YK. New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915.Mar Drugs. 2018 Dec 3;16(12).

11. Niu S, Fan Z, Tang X, Liu Q, Shao Z, Liu G, Yang X. Cyclopiane-type diterpenes from the deep-sea-derived fungus Penicillium commune MCCC 3A00940. Tetrahedron Letters, 2018(59):375-378

12. Jian H, Li S, Tang X, Xiao X. Microarray analysis of the benthic bacterium Shewanella piezotolerans WP3 at low temperature. Mar Genomics. 2017, dx.doi.org/10.1016/j.margen. 2017.01.005.

13. Jian H, Li S, Tang X, Xiao X. Time-series transcriptomic analysis of the deep-sea bacterium Shewanella piezotolerans WP3 in response to high salinity stress.Mar Genomics. 2017, dx.doi.org/10.1016/j.margen.2017.03.001

14. Jian H, Li S, Tang X, Xiao X.A transcriptome resource for the deep-sea bacterium Shewanella piezotolerans WP3 under cold and high hydrostatic pressure shock stress.Mar Genomics. 2016 Dec;30:87-91.

15. Yan X, Zhou YX, Tang X, Liu XX, Yi ZW, Fang MJ, Wu Z, Jiang FQ, Qiu YK. Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression.Mar Drugs. 2016 Oct 26;14(11).

16. Liu D, Lin H, Proksch P, Tang X, Shao Z, Lin W.Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T).Org Lett. 2015 Mar 6;17(5):1220-3.

17. Wang Y, Tang X, Shao Z, Ren J, Liu D, Proksch P, Lin W.Indole-based alkaloids from deep-sea bacterium Shewanella piezotolerans with antitumor activities.

J Antibiot (Tokyo). 2014 May;67(5):395-9.

六、授权的发明专利：

1. 汤熙翔， 丘鹰昆， 晏霞， 易志伟，吴振。 具有抗茶叶治病真菌活性的大环内酯化合物及制备与用途， ZL201610268176.4

2. 汤熙翔，邓钦文，易志伟。一株对茶叶病源真菌具有抗性的深海沉积物来源枯草芽孢杆菌B5，ZL201210432271.5

3. 汤熙翔，邓钦文，易志伟。一株具有抗茶叶致病真菌活性的深海沉积物来源淡紫拟青霉A65，ZL 201210432272.X

4. 汤熙翔，易志伟，李宁。一株产具有细胞毒活性化合物黑麦酮酸F的深海来源青霉菌F11， ZL 201010566995.X